Detalhe da pesquisa
1.
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Cell
; 184(2): 460-475.e21, 2021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33278358
2.
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
Blood
; 143(19): 1953-1964, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38237141
3.
Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome.
Nucleic Acids Res
; 52(3): 1207-1225, 2024 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38117983
4.
Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages.
J Biol Chem
; 299(8): 104984, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37390988
5.
Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi-Goutières syndrome SAMHD1 dNTPase ortholog.
J Biol Chem
; 299(9): 105148, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37567474
6.
Informatics and Computational Approaches for the Discovery and Optimization of Natural Product-Inspired Inhibitors of the SARS-CoV-2 2'-O-Methyltransferase.
J Nat Prod
; 87(2): 217-227, 2024 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38242544
7.
Elimination of Aicardi-Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication.
J Biol Chem
; 298(3): 101635, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35085552
8.
Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs).
Bioorg Chem
; 141: 106923, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37871391
9.
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template.
J Biol Chem
; 297(1): 100770, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33989635
10.
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
J Biol Chem
; 297(4): 101170, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34492268
11.
Randomized Trial of Ruxolitinib in Antiretroviral-Treated Adults With Human Immunodeficiency Virus.
Clin Infect Dis
; 74(1): 95-104, 2022 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33693561
12.
Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial.
J Intern Med
; 292(6): 925-940, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35934913
13.
Assessment of a Computational Approach to Predict Drug Resistance Mutations for HIV, HBV and SARS-CoV-2.
Molecules
; 27(17)2022 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36080181
14.
ß-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells.
J Infect Dis
; 224(3): 415-419, 2021 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33961695
15.
Mechanistic cross-talk between DNA/RNA polymerase enzyme kinetics and nucleotide substrate availability in cells: Implications for polymerase inhibitor discovery.
J Biol Chem
; 295(39): 13432-13443, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32737197
16.
Viral protein X reduces the incorporation of mutagenic noncanonical rNTPs during lentivirus reverse transcription in macrophages.
J Biol Chem
; 295(2): 657-666, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31806704
17.
Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X.
J Biol Chem
; 295(50): 16975-16986, 2020 12 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33008888
18.
Use of Baricitinib in Patients With Moderate to Severe Coronavirus Disease 2019.
Clin Infect Dis
; 72(7): 1247-1250, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32597466
19.
Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens.
Emerg Infect Dis
; 27(11): 2887-2891, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34424838
20.
COVID-19: Discovery, diagnostics and drug development.
J Hepatol
; 74(1): 168-184, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33038433